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1

Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine

Kaddurah-Daouk, R, Weinshilboum, R

Journal:

Clinical Pharmacology & Therapeutics

Année:

2015

Langue:

english

Fichier:

PDF, 4.91 MB

english, 2015

2

Pharmacometabolomics: Implications for Clinical Pharmacology and Systems Pharmacology

Kaddurah-Daouk, R, Weinshilboum, R M

Journal:

Clinical Pharmacology & Therapeutics

Année:

2014

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2014

3

Elevated baseline serum glutamate as a pharmacometabolomic biomarker for acamprosate treatment outcome in alcohol-dependent subjects

Nam, H W, Karpyak, V M, Hinton, D J, Geske, J R, Ho, A M C, Prieto, M L, Biernacka, J M, Frye, M A, Weinshilboum, R M, Choi, D-S

Journal:

Translational Psychiatry

Année:

2015

Langue:

english

Fichier:

PDF, 2.28 MB

english, 2015

4

Pharmacometabolomics informs pharmacogenomics

Neavin, Drew, Kaddurah-Daouk, Rima, Weinshilboum, Richard

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 728 KB

english, 2016

5

METHYLATION PHARMACOGENETICS: Catechol O-Methyltransferase, Thiopurine Methyltransferase, and Histamine N-Methyltransferase

Weinshilboum, Richard M., Otterness, Diane M., Szumlanski, Carol L.

Journal:

Annual Review of Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 392 KB

english, 1999

6

Catecholamines

Axelrod, Julius, Weinshilboum, Richard

Journal:

Boston Medical and Surgical Journal

Année:

1972

Langue:

english

Fichier:

PDF, 27.10 MB

english, 1972

7

Catechol O‐Methyltransferase Pharmacogenomics: Challenges and Opportunities

Ho, Ming‐Fen, Weinshilboum, Richard M.

Journal:

Clinical Pharmacology & Therapeutics

Année:

2019

Langue:

english

Fichier:

PDF, 409 KB

english, 2019

8

Inheritance of human platelet thermolabile phenol sulfotransferase (TL PST) activity

R. Arlen Price, Nancy J. Cox, Richard S. Spielman, Jon A. Van Loon, Bonnie L. Maidak, Richard M. Weinshilboum, I. B. Borecki, D. C. Rao

Journal:

Genetic Epidemiology

Année:

1988

Langue:

english

Fichier:

PDF, 809 KB

english, 1988

9

Using the gene ontology to scan multilevel gene sets for associations in genome wide association studies

Daniel J. Schaid, Jason P. Sinnwell, Gregory D. Jenkins, Shannon K. McDonnell, James N. Ingle, Michiaki Kubo, Paul E. Goss, Joseph P. Costantino, D. Lawrence Wickerham, Richard M. Weinshilboum

Journal:

Genetic Epidemiology

Année:

2012

Langue:

english

Fichier:

PDF, 177 KB

english, 2012

10

Phenol sulfotransferase inheritance

Richard Weinshilboum

Journal:

Cellular and Molecular Neurobiology

Année:

1988

Langue:

english

Fichier:

PDF, 443 KB

english, 1988

11

Sulfate and methyldopa metabolism: Metabolite patterns and platelet phenol sulfotransferase activity

Campbell, Norman R C, Sundaram, Rajah S, Werness, Peter G, Van Loon, Jon, Weinshilboum, Richard M

Journal:

Clinical Pharmacology & Therapeutics

Année:

1985

Langue:

english

Fichier:

PDF, 628 KB

english, 1985

12

Sulfation pharmacogenetics: Correlation of human platelet and small intestinal phenol sulfotransferase

Sundaram, Rajah S, Van Loon, Jon A, Tucker, Richard, Weinshilboum, Richard M

Journal:

Clinical Pharmacology & Therapeutics

Année:

1989

Langue:

english

Fichier:

PDF, 745 KB

english, 1989

13

Pharmacogenomics: bench to bedside

Weinshilboum, Richard, Wang, Liewei

Journal:

Nature Reviews Drug Discovery

Année:

2004

Langue:

english

Fichier:

PDF, 320 KB

english, 2004

14

Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes

Freimuth, R R, Wiepert, M, Chute, C G, Wieben, E D, Weinshilboum, R M

Journal:

The Pharmacogenomics Journal

Année:

2003

Langue:

english

Fichier:

PDF, 226 KB

english, 2003

15

Human phenol sulfotransferases SULT1A2 and SULT1A1: Genetic polymorphisms, allozyme properties, and human liver genotype–phenotype correlations

Rebecca B Raftogianis, Thomas C Wood, Richard M Weinshilboum

Journal:

Biochemical Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 392 KB

english, 1999

16

Phenol Sulfotransferase Pharmacogenetics in Humans: Association of CommonSULT1A1Alleles with TS PST Phenotype

Rebecca B. Raftogianis, Thomas C. Wood, Diane M. Otterness, Jon A. Van Loon, Richard M. Weinshilboum

Journal:

Biochemical and Biophysical Research Communications

Année:

1997

Langue:

english

Fichier:

PDF, 136 KB

english, 1997

17

Thermolabile Phenol Sulfotransferase Gene (STM): Localization to Human Chromosome 16p11.2

Ibrahim A. Aksoy, David F. Callen, Sinoula Apostolou, Chengtao Her, Richard M. Weinshilboum

Journal:

Année:

1994

Fichier:

PDF, 178 KB

1994

18

Human Indolethylamine N-Methyltransferase: cDNA Cloning and Expression, Gene Cloning, and Chromosomal Localization

Michael A. Thompson, Eunpyo Moon, Ung-Jin Kim, Jingping Xu, Michael J. Siciliano, Richard M. Weinshilboum

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 468 KB

english, 1999

19

Calcium inhibition of rat liver catechol-O-methyltransferase

Richard M. Weinshilboum, Frederick A. Raymond

Journal:

Biochemical Pharmacology

Année:

1976

Langue:

english

Fichier:

PDF, 601 KB

english, 1976

20

Methyltransferase pharmacogenetics

Richard Weinshilboum

Journal:

Pharmacology & Therapeutics

Année:

1989

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1989

21

Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine.

CL Szumlanski, RM Weinshilboum

Journal:

British Journal of Clinical Pharmacology

Année:

1995

Langue:

english

Fichier:

PDF, 686 KB

english, 1995

22

Metabolomics: A Global Biochemical Approach to Drug Response and Disease

Kaddurah-Daouk, Rima, Kristal, Bruce S., Weinshilboum, Richard M.

Journal:

Annual Review of Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 772 KB

english, 2008

23

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

Lennard, L., Lilleyman, J.S., Van Loon, J., Weinshilboum, R.M.

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 642 KB

english, 1990

24

Methyltransferase pharmacogenetics

Weinshilboum, R.

Journal:

Journal of Basic and Clinical Physiology and Pharmacology

Année:

1992

Langue:

english

Fichier:

PDF, 97 KB

english, 1992

25

Reduced Plasma Dopamine-β-Hydroxylase Activity in Familial Dysautonomia

Weinshilboum, Richard M., Axelrod, Julius

Journal:

Boston Medical and Surgical Journal

Année:

1971

Langue:

english

Fichier:

PDF, 788 KB

english, 1971

26

Triiodothyronine: A Substrate for the Thermostable and Thermolabile Forms of Human Phenol Sulfotransferase*

YOUNG, WILLIAM F., GORMAN, COLUM A., WEINSHILBOUM, RICHARD M.

Journal:

Année:

1988

Langue:

english

Fichier:

PDF, 1.09 MB

english, 1988

27

Human methylenetetrahydrofolate reductase pharmacogenomics: gene resequencing and functional genomics

Martin, Yvette N., Salavaggione, Oreste E., Eckloff, Bruce W., Wieben, Eric D., Schaid, Daniel J., Weinshilboum, Richard M.

Journal:

Pharmacogenetics and Genomics

Année:

2006

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2006

28

Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine

Giacomini, Kathleen M., Yee, Sook Wah, Mushiroda, Taisei, Weinshilboum, Richard M., Ratain, Mark J., Kubo, Michiaki

Journal:

Nature Reviews Drug Discovery

Année:

2016

Langue:

english

Fichier:

PDF, 181 KB

english, 2016

29

Pharmacogenomics to pharmaco-omics: Precision medicine and drug response

Weinshilboum, Richard

Journal:

Drug Metabolism and Pharmacokinetics

Année:

2018

Langue:

english

Fichier:

PDF, 44 KB

english, 2018

30

Augmentation of Physician Assessments with Multi-Omics Enhances Predictability of Drug Response: A Case Study of Major Depressive Disorder

Athreya, Arjun, Iyer, Ravishankar, Neavin, Drew, Wang, Liewei, Weinshilboum, Richard, Kaddurah-Daouk, Rima, Rush, John, Frye, Mark, Bobo, William

Journal:

IEEE Computational Intelligence Magazine

Année:

2018

Langue:

english

Fichier:

PDF, 1.46 MB

english, 2018

31

Therapeutic potential of triterpenoid saponin anemoside B4 from Pulsatilla chinensis

Li, Yan-hong, Han, Qian, Zou, Min, Deng, Li-rong, Weinshilboum, Richard M.

Journal:

Pharmacological Research

Année:

2020

Fichier:

PDF, 4.01 MB

2020

32

Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells : Relation to thiopurine metabolism

Jens Bo Thomsen, Henrik Schrøder, Jon Kristinsson, Bibi Madsen, Carol Szumlanski, Richard Weinshilboum, Jesper Brandt Andersen, Kjeld Schmiegelow

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 107 KB

english, 1999

33

Histamine N-methyltransferase functional polymorphism: Lack of association with schizophrenia

Lan Yan, Carol L. Szumlanski, Sharmon R. Rice, Janet L. Sobell, Herbert M. Lachman, Richard M. Weinshilboum

Journal:

American Journal of Medical Genetics Part A

Année:

2000

Langue:

english

Fichier:

PDF, 77 KB

english, 2000

34

A phase I study of cytembena

Dr. Stephen Frytak, Charles G. Moertel, Allan J. Schutt, David L. Ahmann, James V. Donadio, Richard M. Weinshilboum

Journal:

Année:

1976

Langue:

english

Fichier:

PDF, 536 KB

english, 1976

35

Genetics of red cell COMT activity: Analysis of thermal stability and family data

Richard S. Spielman, Richard M. Weinshilboum, John M. Opitz

Journal:

American Journal of Medical Genetics Part A

Année:

1981

Langue:

english

Fichier:

PDF, 737 KB

english, 1981

36

Major gene model for the inheritance of catechol-o-methyltransferase activity in five large families

Dr. R. M. Siervogel, Richard Weinshilboum, A. F. Wilson, R. C. Elston

Journal:

American Journal of Medical Genetics Part A

Année:

1984

Langue:

english

Fichier:

PDF, 552 KB

english, 1984

37

Linkage relationships between a major gene for catechol-o-methyltransferase activity and 25 polymorphic marker systems

A. F. Wilson, R. C. Elston, Dr. R. M. Siervogel, Richard Weinshilboum, L. J. Ward

Journal:

American Journal of Medical Genetics Part A

Année:

1984

Langue:

english

Fichier:

PDF, 468 KB

english, 1984

38

SLC6A4 variation and citalopram response

D.A. Mrazek, A.J. Rush, J.M. Biernacka, D.J. O'Kane, J.M. Cunningham, E.D. Wieben, D.J. Schaid, M.S. Drews, V.L. Courson, K.A. Snyder, J.L. Black III, R.M. Weinshilboum

Journal:

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Année:

2009

Langue:

english

Fichier:

PDF, 197 KB

english, 2009

39

Prolonged hypouricemia associated with acute chlorprothixene ingestion

Richard M. Weinshilboum, Joseph L. Goldstein, William N. Kelley

Journal:

Arthritis & Rheumatism

Année:

1975

Langue:

english

Fichier:

PDF, 493 KB

english, 1975

40

Interindividual variability in acetaminophen sulfation by human fetal liver: Implications for pharmacogenetic investigations of drug-induced birth defects

Araba A. Adjei, Andrea Gaedigk, Stephen D. Simon, Richard M. Weinshilboum, J. Steven Leeder

Journal:

Birth Defects Research Part A: Clinical and Molecular Teratology

Année:

2008

Langue:

english

Fichier:

PDF, 409 KB

english, 2008

41

Pharmacogenetics of methyl conjugation and thiopurine drug toxicity

Richard Weinshilboum

Journal:

Année:

1987

Langue:

english

Fichier:

PDF, 705 KB

english, 1987

42

Analysis of the distribution of erythrocyte sodium lithium countertransport in a sample representative of the general population

Eric Boerwinkle, Stephen T. Turner, Richard Weinshilboum, Mark Johnson, Elliott Richelson, Dr. Charles F. Sing, D. C. Rao

Journal:

Genetic Epidemiology

Année:

1986

Langue:

english

Fichier:

PDF, 929 KB

english, 1986

43

Major gene polymorphism for human erythrocyte (RBC) thiol methyltransferase (TMT)

Dr. Richard Arlen Price, Richard A. Keith, Richard S. Spielman, Richard M. Weinshilboum, G. P. Vogler, D. C. Rao

Journal:

Genetic Epidemiology

Année:

1989

Langue:

english

Fichier:

PDF, 686 KB

english, 1989

44

Inheritance of human plasma dopamine-β-hydroxylase thermal stability

John P. Vuchetich, Joel Dunnette, Kathryn L. Lunetta, Richard M. Weinshilboum, Dr. R. Arlen Price, G. P. Vogler

Journal:

Genetic Epidemiology

Année:

1991

Langue:

english

Fichier:

PDF, 840 KB

english, 1991

45

Genetic segregation analysis of red blood cell (RBC) histamine N-methyltransferase (HNMT) activity

R. Arlen Price, Mary C. Scott, Richard M. Weinshilboum

Journal:

Genetic Epidemiology

Année:

1993

Langue:

english

Fichier:

PDF, 580 KB

english, 1993

46

Segregation analysis of human red blood cell thiopurine methyltransferase activity

John P. Vuchetich, Richard M. Weinshilboum, Dr. R. Arlen Price

Journal:

Genetic Epidemiology

Année:

1995

Langue:

english

Fichier:

PDF, 670 KB

english, 1995

47

The ubiquitous nature of the progesterone receptor binding factor-1 (RBF-1) in avian tissues

James P. Landers, Malayannan Subramaniam, Barbara Gosse, Rebecca Weinshilboum, Benjamin J. Madden, Thomas C. Spelsberg

Journal:

Journal of Cellular Biochemistry

Année:

1994

Langue:

english

Fichier:

PDF, 1.03 MB

english, 1994

48

A Message from the Finance Committee Chairperson

Weinshilboum, Richard M.

Journal:

Clinical Pharmacology & Therapeutics

Année:

1995

Langue:

english

Fichier:

PDF, 67 KB

english, 1995

49

Pharmacogenetics: inherited variation in amino acid sequence and altered protein quantity*1

WEINSHILBOUM, R

Journal:

Clinical Pharmacology & Therapeutics

Année:

2004

Langue:

english

Fichier:

PDF, 200 KB

english, 2004

50

Human sulfotransferase (SULT) 1A3 pharmacogenetics: Gene duplication and functional genomics

HILDEBRANDT, M, SALAVAGGIONE, O, MARTIN, Y, FLYNN, H, JALAL, S, WIEBEN, E, WEINSHILBOUM, R

Journal:

Clinical Pharmacology & Therapeutics

Année:

2005

Langue:

english

Fichier:

PDF, 59 KB

english, 2005